FHI's local, national, and global partnerships promote research, teaching, and institutional exchanges across borders, languages, and intellectual traditions. 

Pauli Murray Center for History and Social Justice
The Pauli Murray Center is a nationally significant history site, anchored by activist, legal scholar, feminist, poet, and Episcopal priest Rev. Dr. Pauli Murray’s childhood home built by her grandparents in 1898 at 906 Carroll Street in Durham, North Carolina. By connecting history to contemporary human rights issues, the Pauli Murray Center will activate visitors of all ages to stand up for peace, equity and justice. The Pauli Murray Center grew out of the Pauli Murray Project, which was founded at the Duke Human Rights Center at FHI by Barbara Lau and Robin Kirk in 2009. 

Academy of Global Humanities and Critical Theory (AGHCT)
The Academy of Global Humanities and Critical Theory, currently in transition, is founded on the idea that the so-called global age requires critical exchanges among different research fields as well as a radical rethinking of our theoretical tools. A partnership between Duke University, the Department of History and Cultures at the University of Bologna, and the University of Virginia, the Academy also sponsors the annual Summer School in Global Studies and Critical Theory, held at the University of Bologna.

Consortium of Humanities Centers and Institutes (CHCI)
Between 2007 and 2016, the FHI was the administrative base of the CHCI, an international membership organization for university and college-based humanities centers, institutes, and interdisciplinary programs in the humanities with a significant research component. Past FHI Directors Srinivas Aravamudan and Ian Baucom each served as CHCI President, and current Director Ranjana Khanna serves on its Board. CHCI operations relocated to the University of California Berkeley's Townsend Center for the Humanities in 2023.

Duke Kunshan University Humanities Research Center (HRC)
Duke Kunshan University Humanities Research Center (HRC) promotes research and creative expression in the arts and humanities, and encourages interdisciplinary efforts. Working in close partnership with the Franklin Humanities Institute, the HRC functions as a key research bridge between faculty and students at Duke and DKU. In addition, the HRC facilitates co-curricular research training, treating the entire DKU campus as a laboratory for humanities research.

Center for Philosophy, Arts, and Literature (PAL@FHI)
The FHI provides administrative support for PAL, whose mission is to encourage and promote work that places literature, theater, painting, film, and other arts in conversation with philosophy. The Center is directed by Prof. Toril Moi.

HASTAC (Humanities, Arts, Sciences, Technology Alliance and Collaboratory)
HASTAC is an international group of academic organizations dedicated to exploring and sharing information about the use of new media and technology in higher education. HASTAC is co-founded by Cathy Davidson (Ruth F. DeVarney Professor Emerita of Interdisciplinary Studies and former Vice Provost for Interdisciplinary Studies at Duke, and the FHI's founding Co-Director) and David Theo Goldberg (Director of the University of California Humanities Research Institute). From 2006 to 2017, the FHI served as HASTAC's institutional host. Beginning July 1, 2017, HASTAC will be embedded at the Nexus Lab for Digital Humanities and Computational Informatics at Arizona State University.

Wits Institute for Social and Economic Research (WiSER)
The WiSER partnership grew out of the FHI's co-sponsorship of the Johannesburg Workshop in Theory and Criticism, which held its final session in Summer 2015. The FHI's current collaboration with WiSER supports inter-campus visits by Duke and Wits faculty.